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I'm still reviewing this great presentation from @lukew which highlights the reasons he believes we are in a time where we should build for mobile first, rather than the desktop. He put together a nice collection of quotes from respected thought-leaders as support:

"We're just now starting to think about mobile first and desktop second for a lot of our products." - Kate Aronowitz, Design Director of Facebook

"We really need to shift now to start thinking about building mobile first. This is an even bigger shift than the PC revolution." - Kevin Lynch, CTO Adobe

"Create a product, don't re-imagine one for small screens. Great mobile products are created, never ported." - Brian Fling

For a majority of the population, the desktop is still important, but mobile should be top-of-mind especially as we approach 2011. It's also important to keep in mind the variety of mobile devices people are using: a smartphone is very different than a tablet. And, people are using them in different ways: smartphones are most frequently used as a utility, more urgently, while tablets are used in leisure, for exploration.

What do you think? Are you thinking about mobile first, or is desktop still your priority?